Allopregnanolone (AlloP) – DM6 Health


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Allopregnanolone (AlloP)


What is allopregnanolone (AlloP) and what is it used for in the body?

Allopregnanolone (AlloP) is a hormone that is produced by the brain and reproductive organs. It is a metabolite of progesterone, a hormone that is involved in the menstrual cycle and pregnancy. AlloP is also involved in the regulation of many bodily functions, including mood, anxiety, and sleep.

How is AlloP measured in the body?

AlloP can be measured in the body through various laboratory tests, including blood tests and saliva tests. In these tests, AlloP levels are typically measured in nanograms per milliliter (ng/mL).

What is the normal range for AlloP levels in the body?

The normal range for AlloP levels in the body varies depending on the method used to measure it and the specific laboratory that performs the test. In general, normal AlloP levels in the blood are typically between 1 and 20 ng/mL. In saliva, normal AlloP levels are typically between 0.1 and 1.0 ng/mL.

What can cause abnormal AlloP levels in the body?

Abnormal AlloP levels in the body can be caused by a variety of factors, including medical conditions, certain medications, and lifestyle factors (e.g. stress, alcohol use).

How is AlloP related to the diagnosis and treatment of medical conditions?

AlloP has been studied for its potential therapeutic uses in a variety of medical conditions, including premenstrual syndrome (PMS), postpartum depression, and alcohol use disorder. AlloP levels may be measured as part of the diagnostic process for these conditions, and treatment may involve the use of medications that affect AlloP levels in the body.

How is AlloP related to the regulation of mood and anxiety?

AlloP has been shown to have modulatory effects on the brain's GABAergic system, which is involved in the regulation of mood and anxiety. AlloP levels may be affected by various factors, including stress and hormone levels, and may play a role in the development of mood and anxiety disorders.

Are there any potential side effects associated with AlloP supplements?

AlloP supplements are generally considered safe, with few reported side effects. However, more research is needed to fully understand the potential risks and benefits of AlloP supplementation. It is important to consult a healthcare provider before starting any supplement regimen.


"Allopregnanolone." MedlinePlus, U.S. National Library of Medicine,

"Allopregnanolone (AlloP) Test." Mayo Clinic, Mayo Foundation for Medical Education and Research, 26 Mar. 2020,

"Allopregnanolone." Lab Tests Online, American Association for Clinical Chemistry.